Patients with urticaria usually refer to general outpatient clinics. Patients with chronic urticaria are fully evaluated regarding the cause of urticaria whether physical urticaria, spontaneous, or autoimmune cause Assessment of urticaria severity including the daily urticaria score activity. Full blood workups and RUST tests are done for all patients with chronic urticaria. Urticaria clinic service the biological treatment, Omalizumab, an anti-immunoglobulin E antibody, which is recommended for the treatment of chronic urticaria.